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There are several matches for 'tRNA modifying protein'.
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2853 matches
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organism
protein
1)
Homo sapiens
TYW5 -
tRNA
wybutosine-synthesizing
protein
5;
tRNA
hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family.
[a.k.a. ENSP00000420024, TRNA-yW synthesizing protein 5, AK095272]
2)
Homo sapiens
LCMT2 -
tRNA
wybutosine-synthesizing
protein
4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
(By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.
[a.k.a. EC 2.1.1.290, HPA039401, 9836]
3)
Homo sapiens
TRMT12 -
tRNA
wybutosine-synthesizing
protein
2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
[a.k.a. ENST00000521443.1, uc003yra.5, FLJ20772]
4)
Homo sapiens
TYW3 -
tRNA
wybutosine-synthesizing
protein
3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
(By similarity); Belongs to the TYW3 family.
[a.k.a. XP_006710410.1, uc001dgn.4, AAH71765.1]
5)
Homo sapiens
URM1 -
modifier
1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at
tRNA
wobble positions of cytosolic
tRNA
(Lys),
tRNA
(Glu) and
tRNA
(Gln). Serves as sulfur donor in
tRNA
2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to
tRNA
to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like
protein
(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target
proteins
such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves
[a.k.a. ubiquitin related modifier 1, Q9BTM9, NP_001252511.1]
6)
Mus musculus
Tyw5 -
tRNA
wybutosine-synthesizing
protein
5;
tRNA
hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes (By similarity); Belongs to the TYW5 family.
[a.k.a. NM_001302963, ENSMUST00000160118.4, ENSMUST00000163039]
7)
Mus musculus
Trmt12 -
tRNA
wybutosine-synthesizing
protein
2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).
[a.k.a. 68260, 2.5.1.114, tRNA wybutosine-synthesizing protein 2 homolog]
8)
Mus musculus
Lcmt2 -
tRNA
wybutosine-synthesizing
protein
4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
(By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.
[a.k.a. UPI0000195ECE, UPI0000511FEB, EC 2.1.1.290]
9)
Mus musculus
Tyw3 -
tRNA
wybutosine-synthesizing
protein
3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper
modified
guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine
tRNA
(By similarity).
[a.k.a. ENSMUSG00000047583, Q8BSA9, Tyw3-202]
10)
Mus musculus
Urm1 -
modifier
1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at
tRNA
wobble positions of cytosolic
tRNA
(Lys),
tRNA
(Glu) and
tRNA
(Gln). Serves as sulfur donor in
tRNA
2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to
tRNA
to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like
protein
(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target
proteins
such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves
[a.k.a. ENSMUST00000091142.3, ENSMUST00000156944, 2900073H19Rik]
11)
Drosophila melanogaster
Urm1 -
modifier
1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at
tRNA
wobble positions of cytosolic
tRNA
(Lys),
tRNA
(Glu) and
tRNA
(Gln) (By similarity). Serves as sulfur donor in
tRNA
2- thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3 (By similarity). The sulfur is then transferred to
tRNA
to form 2-thiolation of mcm(5)S(2)U (By similarity). Also acts as a ubiquitin-like
protein
(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target
proteins
such as Jafrac1, Ciao1, Eip71CD
[a.k.a. FBgn0053276, Urm1-PB, NP_996018]
12)
Caenorhabditis elegans
C45G9.2 - Uncharacterized
tRNA
-dihydrouridine synthase-like
protein
C45G9.2; Catalyzes the synthesis of dihydrouridine, a
modified
base found in the D-loop of most tRNAs; Belongs to the Dus family.
[a.k.a. 183479, NP_498078, WBGene00016674]
13)
Caenorhabditis elegans
urm-1 -
modifier
1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at
tRNA
wobble positions of cytosolic
tRNA
(Lys),
tRNA
(Glu) and
tRNA
(Gln). Serves as sulfur donor in
tRNA
2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to
tRNA
to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like
protein
(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target
proteins
. The thiocarboxylated form serves as substrate for conjugation and oxidative stress
[a.k.a. F43D9.6, CAX51654, 13191153]
14)
Saccharomyces cerevisiae
TYW1 - S-adenosyl-L-methionine-dependent
tRNA
4-demethylwyosine synthase; Iron-sulfer
protein
required for synthesis of Wybutosine
modified
tRNA
; Wybutosine is a
modified
guanosine found at the 3'-position adjacent to the anticodon of phenylalanine
tRNA
which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; Belongs to the TYW1 family.
[a.k.a. YPL207W, NM_001184021.1, Q08960]
15)
Saccharomyces cerevisiae
TYW3 -
tRNA
wybutosine-synthesizing
protein
3;
tRNA
methyltransferase required for synthesis of wybutosine; a
modified
guanosine found at the 3'-position adjacent to the anticodon of phenylalanine
tRNA
which supports reading frame maintenance by stabilizing codon-anticodon interactions; Belongs to the TYW3 family.
[a.k.a. YGL050W, NP_011465, sce:YGL050W]
16)
Saccharomyces cerevisiae
DUS1 -
tRNA
-dihydrouridine(16/17) synthase [NAD(P)(+)]; Dihydrouridine synthase; member of a widespread family of conserved
proteins
including Smm1p, Dus3p, and Dus4p;
modifies
pre-
tRNA
(Phe) at U17; Belongs to the Dus family. Dus1 subfamily.
[a.k.a. YML080W, tRNA-dihydrouridine synthase 1, NP_013631.1]
17)
Saccharomyces cerevisiae
PPM2 -
tRNA
wybutosine-synthesizing
protein
4; AdoMet-dependent
tRNA
methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a
modified
guanosine found at the 3'-position adjacent to the anticodon of phe-
tRNA
; similarity to Ppm1p.
[a.k.a. YOL141W, EC 2.1.1.290, 854024]
18)
Saccharomyces cerevisiae
TAN1 - Putative
tRNA
acetyltransferase; RNA-binding
protein
required for the formation of the
modified
nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA;
protein
abundance increases in response to DNA replication stress.
[a.k.a. YGL232W, UPI000013B133, sce:YGL232W]
19)
Saccharomyces cerevisiae
URM1 - Ubiquitin-related
modifier
1; Ubiquitin-like
protein
involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to
tRNA
; also functions as a
protein
tag with roles in nutrient sensing and oxidative stress response.
[a.k.a. YIL008W, CAA86243.1, 854809]
20)
Saccharomyces cerevisiae
TRM1 -
tRNA
(guanine(26)-N(2))-dimethyltransferase, mitochondrial;
tRNA
methyltransferase; two forms of
protein
are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce
modified
base N2,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body (SPB) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB.
[a.k.a. YDR120C, tRNA(guanine-26,N(2)-N(2)) methyltransferase, S000002527]
2853 matches
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